Description

Sphingofungin A is a potent, naturally occurring sphingosine analog and a specific inhibitor of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme in sphingolipid biosynthesis. This targeted mechanism of action makes it a critical research tool for studying sphingolipid metabolism, cellular signaling, and associated disease pathways. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life science sectors, particularly those focused on metabolic disorders, oncology, and antifungal drug discovery.

Application

• Biochemical Research: A key tool compound for investigating the role of sphingolipids in cell proliferation, apoptosis, and differentiation.
• Drug Discovery: Used as a lead compound or reference standard in the development of novel antifungal and anticancer therapeutics targeting sphingolipid synthesis.
• Mechanistic Studies: Employed to elucidate cellular signaling pathways and validate SPT as a therapeutic target in various disease models.
• Academic Research: Utilized in university and institutional labs for fundamental studies in lipid biochemistry and cell biology.
• Pharmaceutical Development: Serves as a critical reference material for analytical method development and quality control in related API synthesis.

Basic Information

Product Name	Sphingofungin A
CAS No.	121025-44-3
Molecular Formula	C21H39NO5
Molecular Weight	385.55 g/mol
Synonyms	(2S,3R,4E)-2-Amino-3-hydroxy-4-octadecene-1,3-diol 1-(2-Hydroxy-3-methylbutanoate); Sphingofungin A; Sphingofungin; ISP-I; Myriocin analog; Serine palmitoyltransferase inhibitor; Thermozymocidin
EINECS	Contact for details

Quality Control

Our Sphingofungin A is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.