Description

5,6-Dichloro-1-β-D-Ribofuranosylbenzimidazole-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is a high-purity, stereochemically defined nucleotide analog of significant research interest. This compound serves as a crucial biochemical tool for investigating cyclic nucleotide-dependent signaling pathways, particularly as a selective activator or inhibitor of specific protein kinases. It is primarily utilized by research scientists and pharmaceutical developers in the fields of cell biology, signal transduction research, and drug discovery. The Rp-isomer configuration provides specific antagonistic properties against protein kinase A (PKA), making it essential for mechanistic studies.

Application

• Biochemical Research: As a potent and selective activator of cGMP-dependent protein kinase (PKG) and an inhibitor of cAMP-dependent protein kinase (PKA) for studying intracellular signaling mechanisms.
• Pharmaceutical Development: Used as a reference standard and a key intermediate in the synthesis of novel therapeutics targeting cardiovascular diseases and neurological disorders.
• Enzymology Studies: Employed as a substrate analog to investigate the specificity and kinetics of phosphodiesterases and other nucleotide-metabolizing enzymes.
• Cell Signaling Pathway Analysis: A critical tool for dissecting the roles of cyclic nucleotides in processes like platelet aggregation, smooth muscle relaxation, and gene expression.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in molecular biology and pharmacology.
• Diagnostic Reagent Manufacturing: Potential use as a component in high-sensitivity assay kits for measuring kinase activity.

Basic Information

Product Name	5,6-Dichloro-1-β-D-Ribofuranosylbenzimidazole-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	120912-55-2
Molecular Formula	C12H11Cl2N2O6PS.Na
Molecular Weight	467.66 g/mol
Synonyms	Rp-8-(5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole)-3',5'-cyclic monophosphorothioate sodium salt; Rp-5,6-DCl-cBiMPS sodium salt; Rp-8-(5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole)-3',5'-cyclic monophosphorothioate sodium salt; Sodium (Rp)-5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole-3',5'-cyclic phosphorothioate; cBiMPS, Rp-isomer, sodium salt; Rp-cBiMPS sodium salt; 8-(5,6-Dichloro-1-β-D-ribofuranosylbenzimidazolyl)-3',5'-cyclic monophosphorothioate, Rp-isomer, sodium salt.
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical adheres to stringent quality protocols to ensure batch-to-batch consistency and research-grade purity. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, isomeric purity, and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Isomeric Purity (Rp-isomer)	≥ 98%
Water Content (KF)	≤ 3.0%
Assay (HPLC/UV)	≥ 90% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.