Description

N(2)-(Pyridyloxobutyl)Deoxyguanosine is a modified nucleoside derivative, specifically an adduct of deoxyguanosine. This compound is of significant interest in biochemical and toxicological research as a marker for DNA damage. It serves as a critical reference standard and reagent for scientists investigating the mechanisms of carcinogenesis, mutagenesis, and the metabolic pathways of specific xenobiotics. Primary users include research institutions, pharmaceutical R&D departments, and analytical laboratories focused on genetic toxicology and biomarker discovery.

Application

• Biomarker Research: Used as a quantitative standard for the detection and measurement of specific DNA adducts in biological samples, aiding in exposure and risk assessment studies.
• Toxicology Studies: Essential for in vitro and in vivo research on the genotoxic effects of certain chemicals, helping to elucidate their mechanisms of action.
• Analytical Method Development: Serves as a high-purity reference material for calibrating analytical instruments like LC-MS/MS and HPLC in method validation for adductomics.
• Pharmacokinetic & Metabolic Research: Employed in studies to understand the metabolic activation and detoxification pathways of compounds that form this specific adduct.
• Standards Manufacturing: Used by manufacturers of diagnostic kits and certified reference materials (CRMs) for quality control and standardization.

Basic Information

Product Name	N(2)-(Pyridyloxobutyl)Deoxyguanosine
CAS No.	120789-94-8
Molecular Formula	C19H24N6O5
Molecular Weight	416.43 g/mol
Synonyms	1,N2-(1-Oxo-4-(3-pyridyl)butyl)-2'-deoxyguanosine; 1,N2-(1-Oxo-4-(pyridin-3-yl)butyl)-2'-deoxyguanosine; N2-(Pyridyloxobutyl)-2'-deoxyguanosine; 3'-dGMP-POB Adduct; dG-POB; POB-dG; N-(Deoxyguanosin-8-yl)-4-(3-pyridyl)butan-1-one; 4-(3-Pyridyl)-4-oxobut-1-yl-deoxyguanosine Adduct
EINECS	Contact for details

Quality Control

Our N(2)-(Pyridyloxobutyl)Deoxyguanosine is produced under strict quality management protocols to ensure the high purity and consistency required for sensitive research applications. Each batch is characterized using advanced analytical techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.