Description

(E)-3-(2-Fluoro-Phenyl)-Acryloyl Chloride is a high-purity, reactive chemical intermediate featuring a fluorinated aromatic ring and an acryloyl chloride functional group. This compound is critical for introducing the (E)-3-(2-fluorophenyl)acryloyl moiety into target molecules, enabling precise structural modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with unique optical or electronic properties.
• Chemical Biology Probes: Employed in the creation of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Peptide & Protein Modification: Facilitates the site-specific acylation of amino groups in peptides, proteins, and other biomolecules for conjugation and labeling applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	(E)-3-(2-Fluoro-Phenyl)-Acryloyl Chloride
CAS No.	120681-05-2
Molecular Formula	C9H6ClFO
Molecular Weight	184.59 g/mol
Synonyms	(E)-3-(2-Fluorophenyl)acryloyl chloride; trans-3-(2-Fluorophenyl)propenoyl chloride; 2-Fluorocinnamoyl chloride; (E)-2-Fluorocinnamoyl chloride; (E)-3-(2-Fluorophenyl)-2-propenoyl chloride; (2E)-3-(2-Fluorophenyl)prop-2-enoyl chloride; (E)-3-(o-Fluorophenyl)acryloyl chloride
EINECS	Contact for details

Quality Control

Every batch of (E)-3-(2-Fluoro-Phenyl)-Acryloyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (by HPLC/NMR), isomeric purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
(E)-Isomer Content (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.