Description

1,N(2)-Propanodeoxyguanosine is a chemically modified nucleoside derivative, specifically a propanodeoxy analog of deoxyguanosine. This compound is a valuable building block in oligonucleotide synthesis and medicinal chemistry research, enabling the study of DNA structure, function, and damage. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and advanced biochemical tools.

Application

• Oligonucleotide Synthesis: Serves as a modified phosphoramidite monomer for the solid-phase synthesis of custom DNA and RNA sequences with site-specific modifications.
• Medicinal Chemistry & Drug Discovery: Used as a key intermediate in the research and development of nucleoside-based antiviral agents, anticancer prodrugs, and other therapeutic candidates.
• Biochemical Research: Employed in studies investigating DNA adduct formation, repair mechanisms, and the structural/functional impact of base modifications.
• Diagnostic Probe Development: Incorporated into nucleic acid probes to enhance stability, alter hybridization properties, or introduce reporter groups for detection.
• Academic Research: A critical reagent for universities and research institutes focusing on molecular biology, genetics, and chemical biology.

Basic Information

Product Name	1,N(2)-Propanodeoxyguanosine
CAS No.	120667-07-4
Molecular Formula	C13H17N5O4
Molecular Weight	307.31 g/mol
Synonyms	1,N2-Propanodeoxyguanosine; 1,N(2)-Propano-2'-deoxyguanosine; 1,N2-Propano-2'-deoxyguanosine; dG-1,N2-Propano adduct; 1,N2-Propanodeoxyguanosine adduct; 1,N2-Propano-dG; 2'-Deoxy-1,N2-propano-guanosine
EINECS	Contact for details

Quality Control

Our 1,N(2)-Propanodeoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.