Description

5-[3-(Trifluoroacetyl)Aminopropyn-1-Yl]Uridine is a specialized nucleoside derivative, a key building block in advanced pharmaceutical and biochemical research. Its modified uridine structure, featuring a trifluoroacetyl-protected propargylamine side chain, makes it a critical intermediate for synthesizing novel oligonucleotides and prodrugs. This compound is essential for researchers and manufacturers in the fields of antiviral drug development, antisense oligonucleotide synthesis, and proteomics research, where precise molecular modifications are required.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified monomer for incorporating specific functionalities into antisense oligonucleotides and siRNAs.
• Bioconjugation & Labeling: The alkyne group enables click chemistry reactions for labeling biomolecules in proteomics and diagnostic assay development.
• Medicinal Chemistry Research: Serves as a building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Probe Development: Utilized in creating probes to study enzyme mechanisms and nucleic acid interactions.

Basic Information

Item	Details
Product Name	5-[3-(Trifluoroacetyl)Aminopropyn-1-Yl]Uridine
CAS No.	120609-05-4
Molecular Formula	C14H14F3N3O7
Molecular Weight	393.27 g/mol
Synonyms	5-[3-(Trifluoroacetamido)prop-1-yn-1-yl]uridine; 5-(3-Trifluoroacetamidoprop-1-ynyl)uridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-((3-(2,2,2-trifluoroacetamido)prop-1-yn-1-yl)pyrimidine-2,4(1H,3H)-dione; Uridine, 5-[3-[(trifluoroacetyl)amino]-1-propynyl]-; Modified Uridine Nucleoside; Trifluoroacetyl-protected Propargylamino Uridine
EINECS	Contact for details

Quality Control

Our 5-[3-(Trifluoroacetyl)Aminopropyn-1-Yl]Uridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements of research and cGMP-grade production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.