Description

Quinupristin is a semi-synthetic streptogramin antibiotic belonging to the Group B (or streptogramin B) class. It is a critical component of the synergistic injectable antibacterial combination, Quinupristin/Dalfopristin, used to combat serious Gram-positive infections. This compound is essential for pharmaceutical manufacturers developing advanced antibiotic formulations to address multidrug-resistant pathogens. Its primary application is in the synthesis of the final drug product for clinical use in hospital settings.

Application

• Active Pharmaceutical Ingredient (API): Primary use as a key component in the manufacture of the injectable antibiotic combination Quinupristin/Dalfopristin.
• Antimicrobial Research: Serves as a reference standard and building block in R&D for novel streptogramin-based therapies and mechanism of action studies.
• Veterinary Medicine: Potential application in developing treatments for bacterial infections in animals, subject to regional regulatory approvals.
• Microbiological Studies: Used in laboratory settings to study bacterial resistance patterns and the efficacy of combination antibiotic therapies.

Basic Information

Product Name	Quinupristin
CAS No.	120138-50-3
Molecular Formula	C53H67N9O10S
Molecular Weight	1022.23 g/mol
Synonyms	RP 57669; Quinupristin component; Streptogramin B; (3R,4S,5R,8R,9S,10E,12E,14S,15S)-15-[[(2S,5R)-5-(dimethylamino)tetrahydro-2-furanyl]methoxy]-14-ethyl-4,12,14-trihydroxy-3,5,9,11-tetramethyl-1-oxa-6-azacyclopentadeca-10,12-diene-2,7-dione; Synercid component; Quinupristin (RP 57669); Antibiotic RP 57669
EINECS	Contact for details

Quality Control

Our Quinupristin is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols include identity confirmation, purity assessment, and impurity profiling to ensure batch-to-batch consistency and compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing all test results, including assay, related substances, residual solvents, and microbiological data, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbial Limits	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.