Description

1-Benzothiophene-7-Carbonyl Chloride is a high-purity, reactive organic intermediate characterized by its acid chloride functional group fused to a benzothiophene core. This compound matters as a critical building block for the synthesis of complex molecules, enabling the introduction of the benzothiophene-7-carboxylic acid moiety under mild conditions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate the benzothiophene scaffold for enhanced activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic semiconductors, conductive polymers, and liquid crystals.
• Chemical Biology & Proteomics: Employed as a derivatization reagent or linker for modifying peptides, proteins, or other biomolecules in probe development.
• Organic Synthesis: Versatile reagent for amide bond formation, esterification, and other nucleophilic acyl substitution reactions in complex molecule assembly.

Basic Information

Product Name	1-Benzothiophene-7-Carbonyl Chloride
CAS No.	120081-47-2
Molecular Formula	C9H5ClOS
Molecular Weight	196.65 g/mol
Synonyms	Benzo[b]thiophene-7-carbonyl chloride; 7-Benzothiophenecarbonyl chloride; 1-Benzothiophene-7-carboxylic acid chloride; 7-Carboxybenzothiophene chloride; Thianaphthene-7-carbonyl chloride; 7-(Chlorocarbonyl)benzo[b]thiophene; BTS-7-COCl
EINECS	Contact for details

Quality Control

Our 1-Benzothiophene-7-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and reactive nature, this material should be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from moisture, strong bases, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	95.0 - 102.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.