Description

Adenosine, 5'-o-[(1,1-Dimethylethyl)Diphenylsilyl]- is a key protected nucleoside derivative, specifically designed for advanced organic synthesis and pharmaceutical research. This compound is crucial for the controlled functionalization of adenosine, enabling the synthesis of complex nucleotide analogs and oligonucleotides with high precision. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and agrochemical industries for developing novel therapeutics and molecular probes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel adenosine receptor agonists/antagonists and other nucleoside-based drug candidates.
• Oligonucleotide Synthesis: Serves as a protected monomer in solid-phase and solution-phase synthesis of antisense oligonucleotides, siRNA, and aptamers.
• Bioconjugation & Probe Development: Used to create labeled nucleotides for diagnostic assays, imaging agents, and biochemical research tools.
• Process Chemistry & Scale-up: Enables the large-scale, GMP-compliant production of active pharmaceutical ingredients (APIs) requiring specific adenosine modifications.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry for studying nucleotide metabolism and enzyme mechanisms.

Basic Information

Product Name	Adenosine, 5'-o-[(1,1-Dimethylethyl)Diphenylsilyl]-
CAS No.	119898-65-6
Molecular Formula	C26H31N5O4Si
Molecular Weight	505.65 g/mol
Synonyms	5'-O-(tert-Butyldiphenylsilyl)adenosine; TBDPS-Adenosine; N6-Benzoyl-5'-O-(tert-butyldiphenylsilyl)adenosine (common protected form); Adenosine, 5'-O-[(1,1-dimethylethyl)diphenylsilyl]-; 9-β-D-Ribofuranosyladenine, 5'-O-(tert-butyldiphenylsilyl) ether; TBDPS-Ado; Protected Adenosine Derivative
EINECS	Contact for details

Quality Control

Our Adenosine, 5'-o-[(1,1-Dimethylethyl)Diphenylsilyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is sensitive to fluoride ions and strong alkali; ensure it is stored separately from such reagents. For long-term storage under inert atmosphere, consider.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.