Description

n-(2-Phenoxyacetyl)Guanosine is a chemically modified nucleoside derivative, specifically a guanosine analog with a phenoxyacetyl protecting group. This compound is a crucial synthetic intermediate in the production of oligonucleotides and modified RNA molecules, enabling advanced research and therapeutic development. It is essential for pharmaceutical R&D, biotechnology companies, and academic institutions focused on antisense technology, siRNA, and mRNA-based applications.

Application

• Solid-Phase Oligonucleotide Synthesis: A key phosphoramidite precursor for introducing modified bases into synthetic oligonucleotides.
• Antisense & siRNA Drug Development: Used in the research and manufacturing of therapeutic oligonucleotides designed for gene silencing.
• mRNA Vaccine & Therapeutic Research: Serves as a building block for creating modified nucleosides that can enhance mRNA stability and reduce immunogenicity.
• Biochemical Research: A tool compound for studying RNA structure, function, and RNA-protein interactions.
• Diagnostic Probe Synthesis: Utilized in the creation of labeled probes for genetic testing and molecular diagnostics.
• Pharmaceutical Intermediates: An important intermediate in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-(2-Phenoxyacetyl)Guanosine
CAS No.	119824-66-7
Molecular Formula	C18H19N5O6
Molecular Weight	401.38 g/mol
Synonyms	N2-(2-Phenoxyacetyl)guanosine; Guanosine, N-(phenoxyacetyl)-; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(2-phenoxyacetamido)-1H-purin-2-one; 2-Amino-6-(2-phenoxyacetamido)-9-β-D-ribofuranosylpurine; N-Phenoxyacetylguanosine; N2-Phenoxyacetylguanosine; N-(Phenoxyacetyl)guanosine; Guanosine N2-(phenoxyacetate)
EINECS	Contact for details

Quality Control

Our n-(2-Phenoxyacetyl)Guanosine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.