Description

5'-Deoxy-5'-Fluoro-5'-(Methylthio)Adenosine is a chemically modified nucleoside analog of significant interest in medicinal chemistry and biochemical research. This compound, with CAS number 119771-21-0, serves as a versatile building block and a key intermediate in the synthesis of novel therapeutic agents and biochemical probes. It is primarily sought after by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers engaged in developing antiviral, anticancer, and enzyme-targeting compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving S-adenosylmethionine (SAM)-dependent methyltransferases and related enzymes.
• Probe Development: Serves as a building block for creating fluorescent or affinity-labeled probes to study nucleic acid metabolism and protein interactions.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of nucleoside analogs.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.

Basic Information

Item	Details
Product Name	5'-Deoxy-5'-Fluoro-5'-(Methylthio)Adenosine
CAS No.	119771-21-0
Molecular Formula	C12H16FN5O3S
Molecular Weight	329.35 g/mol
Synonyms	5'-Deoxy-5'-fluoroadenosine 5'-(methylthioether); 5'-S-Methyl-5'-thio-5'-fluoroadenosine; 5'-Fluoro-5'-(methylthio)adenosine; 5'-Deoxy-5'-fluoro-5'-methylthioadenosine; 5'-Fluoro-5'-deoxy-5'-(methylthio)adenosine; 5'-Methylthio-5'-fluoroadenosine; 5'-Fluoro-MTA; 9-[(5-Deoxy-5-fluoro-5-methylthio-β-D-ribofuranosyl)]adenine
EINECS	Contact for details

Quality Control

Our 5'-Deoxy-5'-Fluoro-5'-(Methylthio)Adenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.