Description

2',3'-Dideoxy-2',3'-Diazidoadenosine is a chemically modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical synthetic intermediate and a versatile building block for the creation of novel nucleotide-based probes and potential therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in antiviral drug discovery, nucleic acid chemistry, and the synthesis of modified oligonucleotides.

Application

• Antiviral Research: As a key precursor in the synthesis of dideoxynucleoside analogs, which are investigated for their potential activity against retroviruses like HIV.
• Nucleic Acid Chemistry: A fundamental building block for constructing modified oligonucleotides with altered backbone structures for mechanistic studies and probe development.
• Biochemical Probe Synthesis: Used to create photoaffinity or click-chemistry compatible probes for studying enzyme-nucleic acid interactions, such as those involving polymerases and reverse transcriptases.
• Medicinal Chemistry: Serves as a core scaffold for the design and synthesis of novel nucleoside-based drug candidates targeting viral and cellular polymerases.
• Chemical Biology Tool Development: Employed in the generation of metabolic labeling agents to track nucleotide incorporation in living cells.

Basic Information

Product Name	2',3'-Dideoxy-2',3'-Diazidoadenosine
CAS No.	119644-21-2
Molecular Formula	C10H11N9O3
Molecular Weight	305.26 g/mol
Synonyms	2',3'-Dideoxy-2',3'-diazidoadenosine; 9-[(2R,3R,5R)-5-(Azidomethyl)-3-azidotetrahydrofuran-2-yl]-9H-purin-6-amine; 2',3'-Diazido-2',3'-dideoxyadenosine; ddAzA; 2',3'-Dideoxy-2',3'-diazidoadenosine; Adenosine, 2',3'-dideoxy-2',3'-diazido-
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-2',3'-Diazidoadenosine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is moisture-sensitive and should be handled under dry conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.