Description

2-Chloro-2',3'-Didehydro-2',3'-Dideoxyadenosine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a versatile scaffold for the creation of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in antiviral and anticancer drug discovery programs. The structural modifications present in this molecule make it a valuable precursor for probing biological mechanisms and developing targeted nucleotide-based therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Research: Investigated as a precursor for potential antiviral agents targeting viral polymerases and reverse transcriptases.
• Oncology Research: Used in the development of chemotherapeutic agents designed to interfere with DNA synthesis and repair in cancer cells.
• Biochemical Tool: Employed in enzymatic studies to understand substrate specificity and inhibition mechanisms of nucleoside kinases and other enzymes.
• Medicinal Chemistry: Serves as a core structure for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	2-Chloro-2',3'-Didehydro-2',3'-Dideoxyadenosine
CAS No.	119530-56-2
Molecular Formula	C10H9ClN5O2
Molecular Weight	266.67 g/mol
Synonyms	2-Chloro-ddA; 2-Chloro-2',3'-didehydro-2',3'-dideoxyadenosine; 2-Cl-ddA; 2-Chloro-2',3'-dideoxyadenosine derivative; 9H-Purin-6-amine, 2-chloro-9-(2,3-didehydro-2,3-dideoxy-β-D-erythro-pentofuranosyl)-; 2-Chloro-D4A
EINECS	Contact for details

Quality Control

Our 2-Chloro-2',3'-Didehydro-2',3'-Dideoxyadenosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your research or development specifications. Our quality systems are designed to support cGMP requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.