Description

1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methylene-Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione is a high-purity nucleoside analog derivative, a key building block in advanced pharmaceutical research and development. Its precise stereochemistry and functional groups make it an essential intermediate for synthesizing novel antiviral and anticancer therapeutics. This compound is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers focused on nucleoside-based drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Critical starting material for the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in the development of next-generation antiviral agents, particularly for hepatitis and herpesvirus families.
• Oncology Therapeutics: Serves as a key scaffold in the design of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Process Development: Used by fine chemical manufacturers for scaling up production processes under GMP conditions for clinical trial material.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methylene-Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	119410-95-6
Molecular Formula	C10H12N2O5
Molecular Weight	240.21 g/mol
Synonyms	3'-Deoxy-3'-methyleneuridine; 3'-C-Exomethyleneuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; 3'-Deoxy-3'-methylideneuridine; 3'-Methyleneuridine; Uridine, 3'-deoxy-3'-methylene-; (2R,3S,5R)-2-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-(hydroxymethyl)-3-methylenetetrahydrofuran-3-ol
EINECS	Contact for details

Quality Control

Our 1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methylene-Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.