Description

Carbocyclic 2'-Deoxyguanosine 5'-Triphosphate is a modified nucleoside triphosphate analog where the natural ribose sugar moiety is replaced by a carbocyclic ring system. This structural modification enhances its metabolic stability, making it a valuable tool for studying DNA replication and repair mechanisms, particularly as a substrate or inhibitor for viral and cellular polymerases. It is essential for researchers and developers in pharmaceutical discovery, molecular biology, and enzymology who require high-purity, well-characterized biochemical reagents.

Application

• Enzymology Research: Used as a stable substrate or inhibitor in kinetic studies of DNA polymerases, reverse transcriptases, and other nucleic acid-processing enzymes.
• Antiviral Drug Development: Serves as a key intermediate or probe in the research and development of nucleoside analog-based antiviral therapeutics.
• Molecular Biology: Employed in in vitro assays to investigate DNA synthesis, repair pathways, and enzyme fidelity.
• Biochemical Synthesis: Acts as a building block for the enzymatic or chemical synthesis of modified oligonucleotides.
• Diagnostic Assay Development: Utilized in the creation of sensitive detection kits for enzyme activity relevant to virology and oncology research.

Basic Information

Product Name	Carbocyclic 2'-Deoxyguanosine 5'-Triphosphate
CAS No.	118905-01-4
Molecular Formula	C11H17N5O12P3
Molecular Weight	528.19 g/mol
Synonyms	Carbocyclic dGTP; c-dGTP; 2'-Deoxycarbocyclic guanosine 5'-triphosphate; (1S,4R)-4-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)cyclopentane-1,2-diol 1-(trihydrogen diphosphate) 2-(dihydrogen phosphate); Carbovir triphosphate analog; Cyclopentyl dGTP
EINECS	Contact for details

Quality Control

Every batch of Carbocyclic 2'-Deoxyguanosine 5'-Triphosphate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 90% (anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.