Description

O(6)-(2-Cyanoethyl)Guanine is a chemically modified nucleobase derivative, specifically a guanine analog with a cyanoethyl group at the O6 position. This compound is a critical building block and key intermediate in oligonucleotide synthesis, particularly for the preparation of modified DNA and RNA sequences for research and therapeutic applications. It is essential for scientists and manufacturers in the fields of pharmaceutical development, molecular biology research, and diagnostic probe synthesis who require high-purity, reliable intermediates for advanced nucleic acid chemistry.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense & siRNA Therapeutics: Used in the research and production of therapeutic oligonucleotides designed for gene silencing and targeted therapies.
• Molecular Diagnostics: Serves as a component in the manufacture of specialized probes and primers for PCR, sequencing, and hybridization assays.
• Biochemical Research: Employed in studies investigating DNA repair mechanisms, mutagenesis, and the structure-function relationships of nucleic acids.
• Apitamer Development: Used in the synthesis of chemically modified libraries for SELEX processes to develop high-affinity binding molecules.
• Labeling & Detection: Can be utilized to introduce functional handles or labels into nucleic acid sequences for detection and imaging purposes.

Basic Information

Product Name	O(6)-(2-Cyanoethyl)Guanine
CAS No.	118822-55-2
Molecular Formula	C8H8N6O
Molecular Weight	204.19 g/mol
Synonyms	O6-(2-Cyanoethyl)guanine; 2-Amino-6-[(2-cyanoethoxy)purine]; 9H-Purin-6-amine, 2-amino-9-[(2-cyanoethoxy)methyl]-; Guanosine O6-(2-cyanoethyl) derivative; O6-CE-Guanine; Nucleic Acid Modification Reagent; DNA Synthesis Intermediate
EINECS	Contact for details

Quality Control

Our O(6)-(2-Cyanoethyl)Guanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive biochemical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material traceable to relevant standards for research and GMP starting material applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.