Description

2-Iodo-2'-Deoxyadenosine is a halogenated nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate in the synthesis of modified oligonucleotides and potential therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in nucleic acid chemistry, antiviral drug discovery, and radiopharmaceutical development. Its unique structure allows for targeted modifications in DNA sequences, making it a valuable tool for probing biological mechanisms and developing novel treatments.

Application

• Antiviral and Anticancer Drug Discovery: As a key synthetic intermediate in the development of nucleoside-based prodrugs and therapeutic candidates.
• Oligonucleotide Synthesis: Used to incorporate iodine-modified bases into DNA strands for structural studies, antisense applications, and diagnostic probe development.
• Radiopharmaceutical Precursor: Serves as a precursor for radioiodinated compounds used in medical imaging (e.g., SPECT) and targeted radiotherapy.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand polymerase activity and DNA repair mechanisms.
• Cross-linking and Bioconjugation: The iodine moiety can be utilized for photo-cross-linking or further functionalization to create bioconjugates for targeted delivery.
• Standards and Reference Materials: Used as a high-purity analytical standard in quality control laboratories for pharmaceutical development.

Basic Information

Item	Detail
Product Name	2-Iodo-2'-Deoxyadenosine
CAS No.	118706-49-3
Molecular Formula	C10H11IN5O3
Molecular Weight	376.13 g/mol
Synonyms	2-Iodo-2'-deoxyadenosine; 9-[(2R,3S,5R)-3-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-iodo-9H-purin-6-amine; 2-Iododeoxyadenosine; 2-Iodo-dA; 2-I-2'-dA; 2-Iodoadenosine deoxyriboside; 2-Iodo-9-(2-deoxy-β-D-erythro-pentofuranosyl)adenine
EINECS	Contact for details

Quality Control

Our 2-Iodo-2'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.