Description

5-(3-Aminopropyl)-2'-Deoxyuridine is a modified nucleoside analog of significant interest in advanced biochemical research and development. This compound matters for its role as a versatile building block in the synthesis of oligonucleotides and probes, enabling precise molecular targeting and labeling. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in drug discovery, antisense therapy, and molecular biology.

Application

• Oligonucleotide Synthesis: A key intermediate for incorporating modified bases into DNA and RNA strands for research and therapeutic applications.
• Probe Development: Used in the creation of labeled probes for fluorescence in situ hybridization (FISH) and other diagnostic assays.
• Antisense & siRNA Research: Serves as a precursor in the development of novel antisense oligonucleotides and small interfering RNA (siRNA) molecules.
• Bioconjugation: The aminopropyl side chain facilitates conjugation with various reporter molecules, peptides, or solid supports.
• Drug Discovery: Investigated as a component in the development of nucleoside-based antiviral or anticancer agents.
• Academic & Industrial R&D: Fundamental research tool for studying nucleic acid chemistry, enzyme mechanisms, and cellular processes.

Basic Information

Product Name	5-(3-Aminopropyl)-2'-Deoxyuridine
CAS No.	118573-62-9
Molecular Formula	C12H19N3O5
Molecular Weight	285.30 g/mol
Synonyms	5-(3-Aminopropyl)deoxyuridine; 5-(3-Aminopropyl)-2'-deoxyuridine; 2'-Deoxy-5-(3-aminopropyl)uridine; 5-(3-Aminopropyl)dU; N3-(3-Aminopropyl)-2'-deoxyuridine (tautomeric form); dU-APA; APA-dU; 5-APA-2'-dU
EINECS	Contact for details

Quality Control

Our 5-(3-Aminopropyl)-2'-Deoxyuridine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is assured through rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.