Description

Polyguanylic-Uridylic Acid*Potassium/Sodium is a synthetic, double-stranded RNA (dsRNA) analog composed of polyguanylic and polyuridylic acid strands complexed with potassium and sodium counterions. This compound is a critical research tool for studying the immune system's response to viral RNA and dsRNA-mediated signaling pathways. It is primarily utilized by biopharmaceutical researchers and diagnostic developers in the fields of immunology, virology, and vaccine adjuvant development.

Application

• Immunological Research: Used as a potent Toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) agonist to stimulate innate immune responses and study interferon production.
• Vaccine Adjuvant Development: Investigated as a component in novel vaccine formulations to enhance immunogenicity and direct the immune response.
• Virology Studies: Serves as a model for viral double-stranded RNA to understand host-pathogen interactions and antiviral defense mechanisms.
• Cell Signaling Pathways: A key reagent for activating protein kinase R (PKR) and other dsRNA-sensitive pathways in cell culture experiments.
• Diagnostic Reagent Manufacturing: Employed in the production of controls and calibrators for diagnostic assays targeting dsRNA or interferon-related biomarkers.
• Therapeutic Research: Explored in preclinical studies for its potential in cancer immunotherapy and as an immunomodulatory agent.

Basic Information

Product Name	Polyguanylic-Uridylic Acid*Potassium/Sodium
CAS No.	118539-79-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Poly(G)-Poly(U); Poly G:Poly U; Polyguanylic-Polyuridylic Acid Potassium Sodium Salt; Poly I:C Analog; dsRNA Polymer; TLR3 Agonist; Polyriboguanylic-Polyribouridylic Acid; Potassium Sodium Poly(G,U)
EINECS	Contact for details

Quality Control

Our Polyguanylic-Uridylic Acid*Potassium/Sodium is produced under strict quality management protocols. Each batch is characterized to ensure identity, purity, and biological activity, with testing typically including spectrophotometric analysis, endotoxin levels, and biophysical characterization. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or powder
Identification (UV-Vis)	Characteristic absorption spectrum for poly(G) and poly(U)
Assay (A260)	≥ 90% (as polynucleotide)
Double-Stranded Content	≥ 85% (by hypochromicity or other suitable method)
Endotoxin	< 10 EU/mg
Protein Content	< 1%
Solubility	Soluble in sterile, nuclease-free water or buffer
Biological Activity	Confirms TLR3/RIG-I agonist activity in a standardized cell-based assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.