Description

Adenosine-2',3'-Cyclic Monophosphorothioate, Endo/Rp-Isomer Sodium Salt is a chemically modified nucleotide analog where a sulfur atom replaces an oxygen in the phosphate group, creating a phosphorothioate linkage. This modification, particularly in the endo/Rp configuration, is crucial for its role as a potent and selective inhibitor of cyclic nucleotide phosphodiesterases and as a stable analog of cyclic adenosine monophosphate (cAMP) for biochemical research. It is an essential tool compound for researchers and developers in pharmaceutical discovery, enzymology, and molecular biology, enabling the study of cell signaling pathways and enzyme mechanisms.

Application

• Biochemical Research: As a stable, hydrolysis-resistant analog of cAMP for studying cyclic nucleotide-dependent signaling pathways.
• Enzyme Inhibition Studies: Used as a selective inhibitor to investigate the function and kinetics of specific cyclic nucleotide phosphodiesterase (PDE) enzymes.
• Pharmaceutical Development: Serves as a key reference standard and pharmacological tool in drug discovery programs targeting PDEs for conditions like inflammation and cardiovascular disease.
• Cell Signaling Analysis: Employed in cell-based assays to modulate intracellular cAMP levels and analyze downstream effects on protein kinase A (PKA) activity.
• Diagnostic Reagent Manufacturing: Potential use as a component in specialized diagnostic kits for enzymatic activity measurements.

Basic Information

Item	Detail
Product Name	Adenosine-2',3'-Cyclic Monophosphorothioate, Endo/Rp-Isomer Sodium Salt
CAS No.	118275-99-3
Molecular Formula	C10H11N5NaO5PS
Molecular Weight	391.26 g/mol
Synonyms	2',3'-cAMPS, Rp-isomer sodium salt; Adenosine 2',3'-cyclic phosphorothioate, Rp-isomer sodium salt; Rp-2',3'-cAMPS sodium salt; cAMP-S, Rp isomer; Endo-Adenosine-2',3'-cyclic monophosphorothioate Rp-isomer sodium salt; (Rp)-Adenosine-2',3'-cyclic monophosphorothioate sodium salt; AR-cAMPS, Rp-isomer
EINECS	Contact for details

Quality Control

Our Adenosine-2',3'-Cyclic Monophosphorothioate, Endo/Rp-Isomer Sodium Salt is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to in-house specifications aligned with industry best practices for fine biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.