Description

2'-Demethylpiritrexim is a high-purity chemical intermediate and reference standard of significant interest in pharmaceutical research and development. This compound is valued for its role as a key synthetic precursor and a critical tool in biochemical studies, particularly in the investigation of enzyme inhibition mechanisms. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel therapeutic agents and advanced analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of more complex drug candidates and analogs.
• Biochemical Research: Used as a reference standard and inhibitor in enzymatic studies to understand biological pathways.
• Analytical Standard: Employed for method development, validation, and quality control in HPLC, LC-MS, and other analytical techniques.
• Academic Research: Utilized in university and institutional labs for pharmacological and medicinal chemistry projects.
• Process Development: Applied in scaling up synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2'-Demethylpiritrexim
CAS No.	118252-37-2
Molecular Formula	C12H13N5O2
Molecular Weight	259.27 g/mol
Synonyms	2'-Desmethylpiritrexim; PTX Intermediate; 2,4-Diamino-6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine derivative; NSC 366140; Piritrexim Impurity; Antifolate Intermediate; DHFR Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 2'-Demethylpiritrexim is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.