Description

3',5'-Bis-o-(T-Butyldiphenylsilyl)Thymidine is a high-purity, protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound is a critical building block in the production of modified DNA and RNA sequences, offering superior stability and selectivity during complex chemical reactions. It is essential for research and development in pharmaceutical discovery, particularly for antisense oligonucleotide and siRNA therapeutics, as well as for diagnostic probe development.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• siRNA and miRNA Research: Serves as a protected monomer for constructing small interfering RNA (siRNA) and microRNA (miRNA) sequences.
• Diagnostic Probe Manufacturing: Essential for creating labeled and modified nucleic acid probes used in molecular diagnostics and bioassays.
• Medicinal Chemistry: Employed in the synthesis of nucleoside analogs for screening as potential antiviral or anticancer agents.
• Bioconjugation: Acts as a starting material for creating nucleoside-polymer or nucleoside-peptide conjugates.

Basic Information

Product Name	3',5'-Bis-o-(T-Butyldiphenylsilyl)Thymidine
CAS No.	118068-35-2
Molecular Formula	C37H48N2O6Si2
Molecular Weight	672.97 g/mol
Synonyms	3',5'-Di-O-(tert-Butyldiphenylsilyl)thymidine; 1-[(2R,4S,5R)-4-([tert-butyl(diphenyl)silyl]oxy)-5-([tert-butyl(diphenyl)silyl]oxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 3',5'-Bis-O-(tert-butyldiphenylsilyl)thymidine; TBDPS-Thymidine; Thymidine, 3',5'-bis-O-[(1,1-dimethylethyl)diphenylsilyl]-; 3',5'-Di-O-TBDPS-thymidine
EINECS	Contact for details

Quality Control

Our 3',5'-Bis-o-(T-Butyldiphenylsilyl)Thymidine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' compliance needs in GMP-oriented applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is sensitive to fluoride and strong alkali; ensure storage areas are free from such contaminants. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.