Description

3'-Azido-2',3'-Dideoxyuridine 5'-Monophosphate is a chemically modified nucleoside monophosphate analog, a key building block in antiviral and biochemical research. This compound is valued for its role as a chain terminator in nucleic acid synthesis, making it a critical reagent for studying viral replication mechanisms and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on virology and nucleotide chemistry.

Application

• Antiviral Research: Serves as a crucial intermediate in the synthesis and study of nucleoside reverse transcriptase inhibitors (NRTIs) for HIV and other retroviruses.
• Biochemical Probe Development: Used to create labeled or modified nucleotides for investigating DNA/RNA polymerase activity and enzyme kinetics.
• Pharmaceutical Intermediate: Acts as a key synthetic precursor in the development of potential antiviral prodrugs and active pharmaceutical ingredients (APIs).
• Mechanistic Studies: Employed in research to understand the molecular mechanisms of viral inhibition and resistance.
• Nucleotide Library Synthesis: A valuable component for building diverse libraries of modified nucleotides for high-throughput screening in drug discovery.

Basic Information

Product Name	3'-Azido-2',3'-Dideoxyuridine 5'-Monophosphate
CAS No.	117783-53-6
Molecular Formula	C9H11N4O8P
Molecular Weight	334.18 g/mol
Synonyms	3'-Azido-3'-deoxythymidine 5'-monophosphate (AZT-MP); 3'-Azido-2',3'-dideoxy-5'-uridylic acid; AZT 5'-Monophosphate; 3'-N3-2',3'-ddUMP; Azidothymidine monophosphate; 5'-O-Phosphono-3'-azido-2',3'-dideoxyuridine; NSC 684590
EINECS	Contact for details

Quality Control

Our 3'-Azido-2',3'-Dideoxyuridine 5'-Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.