Description

7-Methylguanosine 5'-Diphosphate(1+) is a chemically modified nucleotide derivative of guanosine, featuring a methyl group at the N7 position and a diphosphate moiety. This specific modification makes it a valuable biochemical tool and a key intermediate in the study of RNA cap structure analogs and enzymatic processes. It is primarily utilized by researchers and manufacturers in the life sciences sector for advanced biochemical and pharmaceutical development. The compound is supplied as a high-purity material to ensure reliable and reproducible results in sensitive applications.

Application

• Biochemical Research: Used as a substrate or intermediate in enzymatic studies, particularly those involving RNA capping enzymes, methyltransferases, and kinases.
• Pharmaceutical R&D: Serves as a key building block or reference standard in the development of nucleoside-based therapeutics and antiviral agents.
• RNA Cap Analog Synthesis: Acts as a crucial precursor in the chemical synthesis of modified mRNA cap structures for biotechnology applications.
• Enzyme Mechanism Studies: Employed to investigate the specificity and kinetics of enzymes that process or modify guanosine nucleotides.
• Diagnostic Reagent Manufacturing: May be used in the formulation of specialized reagents for molecular diagnostics and assay kits.
• Reference Standard: Provides a high-purity standard for analytical methods such as HPLC and LC-MS in quality control laboratories.

Basic Information

Product Name	7-Methylguanosine 5'-Diphosphate(1+)
CAS No.	117723-13-4
Molecular Formula	C11H16N5O11P2
Molecular Weight	464.22 g/mol
Synonyms	7-Methyl-GDP; N7-Methylguanosine-5'-diphosphate; 7-Methylguanosine diphosphate; m7GDP; 7-Methyl-GDP(1+); Guanosine, 7-methyl-, 5'-(trihydrogen diphosphate); 5'-O-[(phosphonooxy)phosphinyl]-7-methylguanosine
EINECS	Contact for details

Quality Control

Our 7-Methylguanosine 5'-Diphosphate(1+) is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture should be avoided to maintain stability and purity. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.