Description

3'-Azido-3'-Deoxy-5'-o-β-Glucopyranuronosylthymidine is a specialized nucleoside analog derivative, a key intermediate in the synthesis of complex antiviral and anticancer agents. Its unique structure, combining a thymidine base with an azido sugar and a glucuronic acid moiety, makes it a valuable building block for medicinal chemistry research and pharmaceutical development. This compound is primarily utilized by research institutions and pharmaceutical companies focused on developing novel therapeutics, particularly in the fields of virology and oncology.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Medicinal Chemistry Research: Used as a building block for structure-activity relationship (SAR) studies and the development of prodrugs.
• Biochemical Probe Development: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA synthesis.
• Antiviral Agent Synthesis: Key intermediate for compounds targeting viruses such as HIV, hepatitis, and herpes viruses.
• Labeled Compound Synthesis: Potential starting material for the preparation of radiolabeled or fluorescently tagged probes for biological imaging and tracking.
• Academic & Industrial R&D: Employed in university and corporate laboratories for exploratory research in life sciences and drug discovery programs.

Basic Information

Product Name	3'-Azido-3'-Deoxy-5'-o-β-Glucopyranuronosylthymidine
CAS No.	117675-21-5
Molecular Formula	C₁₆H₂₁N₅O₁₀
Molecular Weight	443.37 g/mol
Synonyms	3'-Azido-3'-deoxy-5'-O-β-D-glucopyranuronosylthymidine; AZT-Glucuronide; 3'-N₃-3'-dT-Glucuronide; Thymidine 5'-(trihydrogen diphosphate), 3'-azido-3'-deoxy-, P'→5'-ester with β-D-glucopyranuronic acid; 5'-O-(β-D-Glucopyranuronosyl)-3'-azido-3'-deoxythymidine; AZT Glucuronide Conjugate; NSC 330836
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-5'-o-β-Glucopyranuronosylthymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.