Description

3'-Acetate-2'-Deoxy-5-Ethynyl-Uridine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical and biochemical research. This compound is valued for its role as a versatile intermediate in the synthesis of novel antiviral and anticancer agents, particularly in the development of nucleoside-based prodrugs and diagnostic probes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleotide chemistry and targeted therapy development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of experimental antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a modified substrate in enzymatic studies and for investigating DNA/RNA synthesis mechanisms.
• Probe Development: The ethynyl group serves as a click chemistry handle for labeling and conjugating biomolecules in diagnostic assay development.
• Prodrug Synthesis: Employed in creating prodrug forms of nucleoside therapeutics to enhance bioavailability and targeting.
• Academic Research: A tool compound for studying cell proliferation, nucleotide metabolism, and related biological pathways.
• Fine Chemical Synthesis: Serves as a specialized building block for custom oligonucleotide synthesis and medicinal chemistry projects.

Basic Information

Product Name	3'-Acetate-2'-Deoxy-5-Ethynyl-Uridine
CAS No.	117626-99-0
Molecular Formula	C14H16N2O7
Molecular Weight	324.29 g/mol
Synonyms	5-Ethynyl-2'-deoxyuridine 3'-acetate; 2'-Deoxy-5-ethynyluridine 3'-acetate; 3'-O-Acetyl-5-ethynyl-2'-deoxyuridine; 5-Ethynyl-3'-O-acetyl-2'-deoxyuridine; EdU 3'-acetate; 5-Ethynyl-2'-deoxy-3'-O-acetyluridine; 3'-Acetyl-5-ethynyl-2'-deoxyuridine; 117626-99-0
EINECS	Contact for details

Quality Control

Our 3'-Acetate-2'-Deoxy-5-Ethynyl-Uridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.