Description

Vadimezan is a synthetic flavonoid derivative and a potent small-molecule vascular disrupting agent (VDA). Its primary value lies in its ability to selectively target and disrupt the established tumor vasculature, leading to rapid tumor necrosis. This mechanism makes it a compound of significant interest in oncology research and drug development. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel cancer therapeutics, particularly in the fields of preclinical studies and combination therapy protocols.

Application

• Oncology Research: A key investigational agent for studying vascular disrupting agents (VDAs) and tumor blood flow inhibition.
• Preclinical Drug Development: Used in in vitro and in vivo models to evaluate anti-tumor efficacy and mechanism of action.
• Combination Therapy Studies: Investigated in conjunction with chemotherapy, radiotherapy, or other targeted agents to enhance overall anti-cancer effects.
• Angiogenesis Research: Serves as a tool compound in studies focused on tumor vasculature biology and anti-angiogenic strategies.
• Reference Standard: Used as a high-purity analytical standard in pharmaceutical quality control and method development.

Basic Information

Product Name	Vadimezan
CAS No.	117570-53-3
Molecular Formula	C19H14O8
Molecular Weight	370.31 g/mol
Synonyms	ASA404; DMXAA; 5,6-Dimethylxanthenone-4-acetic Acid; Flavone Acetic Acid Analogue; 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic Acid; NSC 640488; AC-7700; Vadimezanum
EINECS	Contact for details

Quality Control

Our Vadimezan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.