Description

4-(tert-Butyldimethylsilyloxymethyl)Pyridine is a versatile organosilicon-protected pyridine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which offers exceptional stability under a wide range of reaction conditions while allowing for selective deprotection. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors, where it is used to construct complex molecular architectures with high precision.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system.
• Agrochemical Synthesis: Building block for creating novel pesticides, herbicides, and fungicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used to prepare sophisticated pyridine-based ligands for transition metal catalysis and asymmetric synthesis.
• Material Science Research: Monomer or functionalization agent in the development of organic electronic materials, such as conductive polymers and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Enables the synthesis of tagged or modified nucleosides, nucleotides, and other biomolecules for diagnostic and research applications.
• Custom Synthesis & Scale-up: Ideal for contract research organizations (CROs) and CDMOs requiring reliable, high-purity intermediates for client projects from milligram to kilogram scale.

Basic Information

Product Name	4-(tert-Butyldimethylsilyloxymethyl)Pyridine
CAS No.	117423-41-3
Molecular Formula	C12H21NOSi
Molecular Weight	223.39 g/mol
Synonyms	4-((tert-Butyldimethylsilyloxy)methyl)pyridine; Pyridine, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-; 4-(TBDMS-oxymethyl)pyridine; 4-(Hydroxymethyl)pyridine tert-butyldimethylsilyl ether; 4-Pyridinemethanol, 1-[(1,1-dimethylethyl)dimethylsilyl] ether; 4-(tert-Butyldimethylsilanyloxymethyl)pyridine
EINECS	Contact for details

Quality Control

Every batch of 4-(tert-Butyldimethylsilyloxymethyl)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance with cGMP and ISO guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.