Description

1-(1-(2-Hydroxyethoxy)-3-Azidopropyl)Thymine CAS NO 117068-45-8 is a specialized nucleoside derivative, engineered for advanced bioconjugation and click chemistry applications. Its unique structure, featuring a reactive azide group and a thymine base linked by a hydrophilic spacer, makes it an invaluable building block for the precise modification of biomolecules. This compound is essential for researchers and manufacturers in pharmaceutical development, oligonucleotide synthesis, and diagnostic probe design, where reliable, high-purity intermediates are critical for innovation.

Application

• Bioconjugation Reagent: Used for site-specific labeling of proteins, antibodies, and other biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Oligonucleotide Synthesis: Serves as a modified nucleoside phosphoramidite precursor for introducing functional handles into DNA and RNA strands.
• Probe and Diagnostic Development: Enables the creation of fluorescent or affinity-tagged probes for imaging, detection, and diagnostic assays.
• Polymer and Material Science: Acts as a functional monomer for synthesizing smart polymers and biomaterials with tailored biological interactions.
• Antiviral and Anticancer Research: Investigated as a potential intermediate in the synthesis of novel nucleoside analog therapeutics.
• Chemical Biology Tool: Facilitates the study of biomolecular interactions and cellular processes through targeted labeling strategies.

Basic Information

Item	Detail
Product Name	1-(1-(2-Hydroxyethoxy)-3-Azidopropyl)Thymine
CAS No.	117068-45-8
Molecular Formula	C13H19N5O5
Molecular Weight	325.32 g/mol
Synonyms	1-[1-(2-Hydroxyethoxy)-3-azidopropyl]thymine; 3'-Azido-3'-deoxy-5'-O-(2-hydroxyethyl)thymidine; 5'-O-(2-Hydroxyethyl)-3'-azido-3'-deoxythymidine; 3'-Azido-2',3'-dideoxy-5'-O-(2-hydroxyethyl)thymidine; AZT Hydroxyethyl Ether Derivative; Thymine Azido Propyl Hydroxyethoxy Derivative; N1-(3-Azido-1-(2-hydroxyethoxy)propyl)thymine
EINECS	Contact for details

Quality Control

Every batch of 1-(1-(2-Hydroxyethoxy)-3-Azidopropyl)Thymine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive research and development applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles by HPLC, NMR, and mass spectrometry is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing desiccated under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.