Description

Pregna-1,4,9(11)-Triene-3,20-Dione, 21-Chloro-17-Hydroxy-16-Methyl-, (16β)- is a high-purity synthetic steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmaceutical intermediate for the synthesis of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. It is primarily sought by R&D laboratories, CROs, and API manufacturers engaged in developing next-generation steroid-based medications.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid analogs and other specialized steroid APIs.
• Research & Development: Used in academic and industrial research to study structure-activity relationships (SAR) and develop new drug candidates targeting hormonal pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of steroid-based active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	Pregna-1,4,9(11)-Triene-3,20-Dione, 21-Chloro-17-Hydroxy-16-Methyl-, (16β)-
CAS No.	116846-77-6
Molecular Formula	C22H27ClO4
Molecular Weight	390.90 g/mol
Synonyms	21-Chloro-16β-methylpregna-1,4,9(11)-triene-3,20-dione-17-ol; 16β-Methyl-21-chloro-1,4,9(11)-pregnatriene-3,20-dione-17α-ol; 21-Chloro-16β-methyl-1,4,9(11)-pregnatriene-3,20-dione-17α-ol; (16β)-21-Chloro-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione; 21-Chloro-16β-methylprednisolone derivative; 16β-Methyl-21-chloro prednisolone analog; 21-Cl-16β-Me-Prednisolone intermediate
EINECS	Contact for details

Quality Control

Our Pregna-1,4,9(11)-Triene-3,20-Dione, 21-Chloro-17-Hydroxy-16-Methyl-, (16β)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and comprehensive identification (IR, NMR), to ensure it meets exacting research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.