Description

Metazosin CAS NO 116728-65-5 is a selective α-1 adrenergic receptor antagonist of significant pharmaceutical interest. This compound matters for its potential role in the research and development of treatments for conditions related to smooth muscle tone and blood pressure regulation. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for preclinical and clinical studies.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the synthesis and study of novel α-1 adrenoceptor antagonists.
• Cardiovascular Drug Discovery: Used in preclinical research for investigating potential therapies for hypertension and benign prostatic hyperplasia (BPH).
• Biochemical Assay Development: Serves as a selective ligand in receptor binding studies and pharmacological profiling assays.
• Academic Pharmacology Studies: Employed in university and institutional research to understand adrenergic signaling pathways.
• Analytical Reference Standard: Provides a high-purity benchmark for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in API manufacturing.

Basic Information

Product Name	Metazosin
CAS No.	116728-65-5
Molecular Formula	C19H25N5O3
Molecular Weight	371.44 g/mol
Synonyms	Metazosin; 2-[4-(2-Methoxyphenyl)piperazin-1-yl]-N-(2-pyrimidin-2-ylaminoethyl)acetamide; 1-(2-Methoxyphenyl)-4-[2-[[(2-pyrimidin-2-ylaminoethyl)amino]-2-oxoethyl]piperazine; BIBX 1382; BIBX-1382; BIBX1382
EINECS	Contact for details

Quality Control

Our Metazosin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.