Description

(2,6-Difluoro-Phenyl)-Acetyl Chloride is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the (2,6-difluorophenyl)acetyl moiety, a key structural motif in active pharmaceutical ingredients and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and polymers for advanced materials with specific thermal or optical properties.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Bioconjugation Chemistry: Can be utilized for modifying biomolecules, peptides, or surfaces through amide bond formation under mild conditions.

Basic Information

Item	Details
Product Name	(2,6-Difluoro-Phenyl)-Acetyl Chloride
CAS No.	116622-90-3
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2,6-Difluorophenylacetyl chloride; (2,6-Difluorophenyl)acetyl chloride; 2-(2,6-Difluorophenyl)acetyl chloride; α-Chloro-2,6-difluoroacetophenone; 2,6-Difluoro-α-chloroacetophenone; 2',6'-Difluorophenacyl chloride; 1-Chloro-2-(2,6-difluorophenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our (2,6-Difluoro-Phenyl)-Acetyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Production adheres to cGMP principles where applicable, and all materials are supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.