Description

Peg2-Bis(Phosphonic Acid) CAS NO 116604-42-3 is a specialized bifunctional organophosphorus compound featuring a short polyethylene glycol (PEG) spacer linking two phosphonic acid groups. This unique structure makes it a valuable chelating agent and surface modifier, offering excellent metal ion binding and hydrophilic properties. It is primarily used by researchers and manufacturers in the pharmaceutical, materials science, and nanotechnology sectors for developing advanced drug delivery systems, functional coatings, and metal-organic frameworks.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel drug conjugates and prodrugs, leveraging its PEG spacer for improved solubility and its phosphonate groups for targeting.
• Metal Chelation & Sequestration: Acts as an effective chelating agent for divalent and trivalent metal ions (e.g., Ca²⁺, Fe³⁺) in industrial water treatment and scale inhibition formulations.
• Surface Functionalization Agent: Employed to modify the surface of nanoparticles, quantum dots, and medical implants to enhance biocompatibility, stability, and specific binding capabilities.
• Ligand for Metal-Organic Frameworks (MOFs): Serves as an organic linker in the construction of MOFs for gas storage, separation, and catalytic applications.
• Crosslinking Agent: Utilized in polymer chemistry to create hydrogels or networks with tailored degradation profiles and metal-binding properties.
• Analytical Chemistry Reagent: Functions as a complexing agent in chromatography and spectroscopy for the separation or detection of metal ions.

Basic Information

Item	Details
Product Name	Peg2-Bis(Phosphonic Acid)
CAS No.	116604-42-3
Molecular Formula	C₄H₁₂O₈P₂
Molecular Weight	250.08 g/mol
Synonyms	1,2-Bis(phosphonoethoxy)ethane; Diethyleneglycol bis(phosphonic acid); Ethane-1,2-diylbis(oxyethane-2,1-diyl)bis(phosphonic acid); Bis(2-phosphonoethyl) ether; PEG2-diphosphonic acid; O,O'-Bis(2-phosphonoethyl)ethylene glycol; (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl)bis(phosphonic acid)
EINECS	Contact for details

Quality Control

Our Peg2-Bis(Phosphonic Acid) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for active content, to ensure it meets precise specifications. Certificates of Analysis (COA) documenting all test results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.