Description

N6-Benzoyl-9-(5-o-Benzoyl-2'-Deoxy-β-D-Threo-Pentofuranosyl)Adenine is a key nucleoside derivative, specifically a protected adenine analog. This compound is essential for researchers and manufacturers in the field of oligonucleotide synthesis, where it serves as a critical building block for the creation of modified DNA and RNA sequences. Its primary value lies in enabling the study of nucleic acid structure, function, and the development of advanced therapeutic agents, making it indispensable for pharmaceutical R&D and biotechnology applications.

Application

• Oligonucleotide Synthesis: Acts as a crucial phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications targeting genetic diseases.
• siRNA and miRNA Research: Serves as a modified nucleoside component in the synthesis of small interfering RNA (siRNA) and microRNA (miRNA) for gene silencing studies.
• Apitamer Development: Incorporated into SELEX libraries for the discovery of nucleic acid aptamers with high binding affinity for specific targets.
• Diagnostic Probe Synthesis: Utilized in creating labeled nucleic acid probes for diagnostic assays and hybridization techniques.
• Chemical Biology Studies: Enables site-specific incorporation of modifications to investigate nucleic acid-protein interactions and enzyme mechanisms.
• Pharmaceutical Intermediate: Functions as a high-purity intermediate in the multi-step synthesis of novel nucleoside-based antiviral or anticancer agents.

Basic Information

Product Name	N6-Benzoyl-9-(5-o-Benzoyl-2'-Deoxy-β-D-Threo-Pentofuranosyl)Adenine
CAS No.	116597-12-7
Molecular Formula	C25H23N5O5
Molecular Weight	473.48 g/mol
Synonyms	5'-O-Benzoyl-2'-deoxy-N6-benzoyladenosine; 2'-Deoxy-N6,5'-O-dibenzoyladenosine; 9-(5-O-Benzoyl-2-deoxy-β-D-threo-pentofuranosyl)-N6-benzoyladenine; N6,5'-Di-O-benzoyl-2'-deoxyadenosine; dA(Bz) Bz; Protected 2'-Deoxyadenosine Derivative; Bz-dA(Bz)
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-9-(5-o-Benzoyl-2'-Deoxy-β-D-Threo-Pentofuranosyl)Adenine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive pharmaceutical and research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of oligonucleotide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.