Description

4-Pyridinecarbonyl Chloride, 1,2,3,6-Tetrahydro-1-Methyl- (9Ci) is a versatile and reactive heterocyclic building block, specifically a functionalized nicotinoyl chloride derivative. Its value lies in its role as a key intermediate for introducing the 1-methyl-1,2,3,6-tetrahydropyridine-4-carbonyl moiety into more complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the synthesis of novel active ingredients, particularly those targeting neurological pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) targets and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold.
• Chemical Research & Development: Serves as a versatile building block for constructing complex heterocyclic compounds and libraries for high-throughput screening.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands for metal complexes and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential use in the development of advanced organic materials and functional polymers.

Basic Information

Product Name	4-Pyridinecarbonyl Chloride, 1,2,3,6-Tetrahydro-1-Methyl- (9Ci)
CAS No.	116576-81-9
Molecular Formula	C7H8ClNO
Molecular Weight	157.60 g/mol
Synonyms	1-Methyl-1,2,3,6-tetrahydropyridine-4-carbonyl chloride; 1-Methyl-4-piperidinecarbonyl chloride; 1-Methyl-4-(chlorocarbonyl)-1,2,3,6-tetrahydropyridine; 4-(Chlorocarbonyl)-1-methyl-1,2,3,6-tetrahydropyridine; Nicotinoyl chloride, 1,2,3,6-tetrahydro-1-methyl-; 1-Methyl-1,2,3,6-tetrahydronicotinoyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Pyridinecarbonyl Chloride, 1,2,3,6-Tetrahydro-1-Methyl- is produced and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity (IR, NMR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.