Description

2'-Deoxy-2',2'-Difluoro-5'-Cytidylic Acid is a high-purity nucleotide analog of critical importance in advanced pharmaceutical synthesis. This compound serves as a key intermediate in the production of modern antiviral and anticancer therapeutics, most notably as the active metabolite of the blockbuster drug Gemcitabine. It is essential for research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development and production of nucleoside-based active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as the active metabolite and a crucial synthetic precursor for the anticancer drug Gemcitabine (Gemzar®).
• Antiviral Drug Synthesis: Serves as a building block in the research and development of novel nucleoside analog antiviral agents.
• Biochemical Research: Used as a reference standard and a tool compound in oncology research, metabolic studies, and mechanism of action investigations.
• Process Development & Scale-Up: Employed in process chemistry for optimizing synthetic routes to fluorinated nucleosides under GMP or non-GMP conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the commercial production of high-value APIs.

Basic Information

Product Name	2'-Deoxy-2',2'-Difluoro-5'-Cytidylic Acid
CAS No.	116371-67-6
Molecular Formula	C9H11F2N3O7P
Molecular Weight	330.17 g/mol
Synonyms	dFdCMP; 2',2'-Difluorodeoxycytidine 5'-monophosphate; Gemcitabine 5'-monophosphate; Gemcitabine monophosphate; 2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate; 5'-O-Phosphono-2'-deoxy-2',2'-difluorocytidine; (2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)-3-fluorotetrahydrofuran-3-yl dihydrogen phosphate
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2',2'-Difluoro-5'-Cytidylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.