Description

5-Aminouridine, Hydrochloride Salt is a modified nucleoside derivative of uridine, where an amino group is introduced at the 5-position of the pyrimidine ring. This specific modification makes it a valuable building block and research chemical for the synthesis of novel nucleoside analogs and oligonucleotides. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery, biochemical studies, and the development of diagnostic probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving nucleoside metabolism and RNA processing.
• Oligonucleotide Synthesis: Serves as a modified monomer for incorporating specific functionalities into DNA or RNA strands for therapeutic or diagnostic applications.
• Probe Development: Utilized in creating labeled nucleosides for fluorescence in situ hybridization (FISH) and other detection methodologies.
• Academic Research: Fundamental studies in organic chemistry, medicinal chemistry, and chemical biology to explore structure-activity relationships.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in laboratories.

Basic Information

Product Name	5-Aminouridine, Hydrochloride Salt
CAS No.	116154-74-6
Molecular Formula	C9H14ClN3O6
Molecular Weight	295.68 g/mol
Synonyms	5-Amino-1-β-D-ribofuranosyluracil hydrochloride; 5-Amino-URidine HCl; 5-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride; 5-Amino-1-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione hydrochloride; 5-Amino-Urd HCl; 5-Amino-β-D-ribofuranosyluracil hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Aminouridine, Hydrochloride Salt is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.