Description

5-[3-(Trifluoroacetamido)-E-1-Propenyl]-2'-Deoxyuridine is a specialized nucleoside derivative, a key synthetic intermediate in the development of novel antiviral and anticancer therapeutics. Its value lies in its role as a versatile building block for modifying the structure and activity of nucleoside analogs, enabling targeted drug discovery. This compound is essential for research and development laboratories in the pharmaceutical and biotechnology sectors, particularly those focused on antiviral agents, oncology research, and prodrug synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a building block for creating chemotherapeutic agents that interfere with DNA synthesis in cancer cells.
• Biochemical Research: Employed in studies of enzyme kinetics and inhibition, particularly involving thymidine kinase and related enzymes.
• Prodrug Synthesis: The trifluoroacetamido and propenyl groups make it a valuable intermediate for designing prodrugs with enhanced bioavailability.
• Labeled Compound Synthesis: Can be used as a starting material for the preparation of isotopically labeled (e.g., C-13, N-15) compounds for metabolic studies.

Basic Information

Product Name	5-[3-(Trifluoroacetamido)-E-1-Propenyl]-2'-Deoxyuridine
CAS No.	115794-55-3
Molecular Formula	C14H15F3N2O6
Molecular Weight	364.28 g/mol
Synonyms	5-[3-(Trifluoroacetamido)-1-Propenyl]-2'-deoxyuridine (E-isomer); 5-(3-Trifluoroacetamidoprop-1-en-1-yl)-2'-deoxyuridine; 2'-Deoxy-5-[3-(trifluoroacetamido)-1-propenyl]uridine; 5-(3-Trifluoroacetamidopropenyl)-2'-deoxyuridine; TFA-dUrd derivative; Nucleoside intermediate 115794-55-3
EINECS	Contact for details

Quality Control

Our 5-[3-(Trifluoroacetamido)-E-1-Propenyl]-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research intermediates. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent analysis are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.