Description

Liarozole is a potent and selective retinoic acid metabolism-blocking agent (RAMBA) with significant pharmacological activity. This compound is crucial for researchers and developers in the pharmaceutical sector due to its targeted mechanism of action. It is primarily utilized in advanced research for investigating and developing novel therapeutic agents, particularly in oncology and dermatology. Liarozole CAS NO 115575-11-6 represents a high-value intermediate for the synthesis of innovative drug candidates.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel drug candidates targeting retinoic acid pathways.
• Oncology Research: Investigated for its potential anti-cancer properties, particularly in studies related to cell differentiation and proliferation.
• Dermatological Applications: Used in research for developing treatments for skin disorders such as psoriasis, acne, and ichthyosis.
• Biochemical Studies: Employed as a tool compound to study the inhibition of cytochrome P450 enzymes, specifically CYP26.
• Preclinical Development: Utilized in animal model studies to evaluate pharmacokinetics, efficacy, and safety profiles of new therapeutic entities.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Liarozole
CAS No.	115575-11-6
Molecular Formula	C₁₇H₁₂Cl₂N₂O
Molecular Weight	331.20 g/mol
Synonyms	(±)-5-[(E)-2-(4-Chlorophenyl)ethenyl]-1H-imidazole; R 75251; R-75251; R75251; Liazal; Liarozole fumarate; 5-[(1E)-2-(4-Chlorophenyl)ethenyl]-1H-imidazole; 5-[(E)-2-(4-Chlorophenyl)vinyl]-1H-imidazole
EINECS	Contact for details

Quality Control

Our Liarozole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity determination by HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.