Description

2-Amino-4-Chloro-7-(2,3-o-Isopropylidene-5-o-tert-Butyldimethylsilyl-D-Ribofuranosyl)Pyrrolo[2,3-d]Pyrimidine CAS NO 115479-40-8 is a sophisticated nucleoside analog building block, a key intermediate in the synthesis of modified oligonucleotides and antiviral agents. Its value lies in its precisely protected ribofuranosyl moiety, which enables selective chemical modifications critical for advanced pharmaceutical research and development. This high-purity compound is essential for medicinal chemists and researchers in the fields of nucleoside chemistry, antiviral drug discovery, and therapeutic oligonucleotide synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside-based antiviral and anticancer therapeutics.
• Antisense Oligonucleotide (ASO) Synthesis: Used in the preparation of modified oligonucleotides for research into gene silencing and RNA-targeted therapies.
• Prodrug Development: Serves as a precursor for prodrugs designed to improve the bioavailability and targeting of nucleoside analogs.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a versatile scaffold for chemical modification.
• Bioconjugation: The reactive amino and chloro groups allow for further functionalization and conjugation with other molecules or delivery systems.
• Chemical Biology Probes: Utilized in the development of labeled or tagged nucleosides for studying biological processes and mechanisms.

Basic Information

Item	Details
Product Name	2-Amino-4-Chloro-7-(2,3-o-Isopropylidene-5-o-tert-Butyldimethylsilyl-D-Ribofuranosyl)Pyrrolo[2,3-d]Pyrimidine
CAS No.	115479-40-8
Molecular Formula	C20H31ClN4O4Si
Molecular Weight	455.03 g/mol
Synonyms	7-(2,3-O-Isopropylidene-5-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-2-amino-4-chloropyrrolo[2,3-d]pyrimidine; 2-Amino-4-chloro-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-2-amino-7-(2,3-O-isopropylidene-5-O-TBDMS-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; TBDMS-Protected 2-Amino-4-chloro-7-(2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; Nucleoside Intermediate 115479-40-8; 2-Amino-4-chloro-7-(2,3-O-isopropylidene-5-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Amino-4-Chloro-7-(2,3-o-Isopropylidene-5-o-tert-Butyldimethylsilyl-D-Ribofuranosyl)Pyrrolo[2,3-d]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.