Description

N2-Phenoxyacetyl-2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically designed for oligonucleotide synthesis and pharmaceutical research. This compound is critical for protecting the exocyclic amine group of deoxyguanosine during solid-phase synthesis, ensuring high coupling efficiency and product purity. It is an essential building block for researchers and manufacturers in the fields of antisense therapy, diagnostic probe development, and synthetic biology.

Application

• Phosphoramidite Synthesis: A key protected intermediate for the preparation of deoxyguanosine phosphoramidites, the standard reagents for automated DNA synthesis.
• Oligonucleotide Manufacturing: Used in the solid-phase synthesis of DNA and RNA strands for therapeutic, diagnostic, and research applications.
• Antisense & siRNA Development: Serves as a critical raw material in the production of antisense oligonucleotides and small interfering RNA (siRNA) for gene silencing studies and drug candidates.
• Diagnostic Probes: Incorporated into the manufacture of labeled probes for PCR, FISH, and microarray technologies.
• Synthetic Biology: Used in the construction of artificial genes, genetic circuits, and modified nucleic acids with novel functions.
• Academic & Industrial R&D: A fundamental reagent for chemical biology research, exploring nucleic acid structure, function, and drug interactions.

Basic Information

Product Name	N2-Phenoxyacetyl-2'-Deoxyguanosine
CAS No.	115389-03-2
Molecular Formula	C18H19N5O6
Molecular Weight	401.38 g/mol
Synonyms	2'-Deoxy-N2-phenoxyacetylguanosine; dG(Pac); N-Pac-dG; N2-(Phenoxyacetyl)-2'-deoxyguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(phenoxyacetamido)-1H-purin-6-one; Pac-dG; Guanosine, 2'-deoxy-, 2-(phenoxyacetate)
EINECS	Contact for details

Quality Control

Our N2-Phenoxyacetyl-2'-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.