Description

Pheac-Dmt-Deoxyadenosine is a protected nucleoside derivative, a key advanced intermediate in oligonucleotide synthesis. Its primary value lies in enabling the precise construction of DNA and RNA sequences for research and therapeutic applications. This high-purity building block is essential for pharmaceutical R&D, biotechnology companies, and academic institutions focused on antisense oligonucleotides, siRNA, and other nucleic acid-based technologies.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A critical phosphoramidite precursor for the automated synthesis of DNA and RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the manufacture of therapeutic oligonucleotides targeting specific mRNA sequences.
• siRNA and miRNA Synthesis: Serves as a protected monomer for constructing short interfering RNA (siRNA) and microRNA (miRNA) molecules.
• Diagnostic Probe Manufacture: Employed in creating labeled DNA probes for diagnostic assays and genomic research.
• Pharmaceutical Intermediate: A vital building block in the production of novel nucleic acid-based drugs and vaccines.
• Academic and Industrial Research: Used in laboratories for studying nucleic acid chemistry, structure, and function.

Basic Information

Product Name	Pheac-Dmt-Deoxyadenosine
CAS No.	115388-94-8
Molecular Formula	C33H33N7O6
Molecular Weight	623.67 g/mol
Synonyms	N6-(Phenoxyacetyl)-5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyadenosine; 2'-Deoxy-N6-(phenoxyacetyl)adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl] derivative; dA(Pac)-DMT; 5'-O-DMT-N6-Pac-2'-deoxyadenosine; N-Pac-5'-O-DMT-deoxyadenosine; Protected Deoxyadenosine Monomer; DNA Synthesis Building Block
EINECS	Contact for details

Quality Control

Our Pheac-Dmt-Deoxyadenosine is manufactured under strict quality systems to ensure consistency and reliability for sensitive synthesis applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high standards suitable for pharmaceutical R&D, with specifications typically meeting or exceeding ≥98.5% HPLC purity. COAs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a desiccated environment to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Water Content (KF)	≤0.5%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.