Description

3'-β-C-Methylguanosine is a chemically modified nucleoside analog of guanosine, featuring a methyl group at the 3'-beta carbon position of the ribose sugar. This specific structural modification is of significant interest in medicinal chemistry and biochemistry for its role as a key intermediate and building block in antiviral and anticancer research. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in the development of novel therapeutic agents, particularly nucleoside-based prodrugs targeting viral polymerases.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of advanced nucleoside analogs for antiviral and anticancer drug discovery programs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate polymerase mechanisms and nucleotide metabolism.
• Antiviral Agent Development: Serves as a core scaffold for developing potential therapeutics against viruses such as hepatitis C virus (HCV) and other RNA viruses.
• Pro-drug Synthesis: Employed in the chemical modification and development of pro-drug forms to enhance bioavailability and targeting.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for pharmaceutical manufacturing.
• Life Science Reagents: Incorporated into specialized kits and reagents for molecular biology and diagnostic assay development.

Basic Information

Product Name	3'-β-C-Methylguanosine
CAS No.	115303-89-4
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	3'-C-Methylguanosine; 3'-β-C-Methylguanosine; 3'-Deoxy-3'-C-methylguanosine; Guanosine, 3'-C-methyl-; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-6,9-dihydro-1H-purin-6-one
EINECS	Contact for details

Quality Control

Our 3'-β-C-Methylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.