Description

2',3'-Dideoxy-3'-Fluoro-5-Methylcytidine is a fluorinated nucleoside analog of significant interest in pharmaceutical research and development. This modified cytidine derivative is valued for its potential role as a key intermediate or active pharmaceutical ingredient (API) in antiviral and anticancer therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and CDMOs engaged in the synthesis of novel nucleoside-based drugs targeting viral replication and cellular proliferation.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced antiviral and antineoplastic nucleoside analogs.
• Antiviral Drug Research: Investigated for its potential activity against a range of viruses, including HIV, hepatitis B (HBV), and hepatitis C (HCV), due to its modified sugar moiety which can inhibit viral polymerase enzymes.
• Oncology Research: Used in the development of chemotherapeutic agents designed to interfere with DNA synthesis in rapidly dividing cancer cells.
• Biochemical Tool: Employed in enzymatic studies to understand the substrate specificity and inhibition mechanisms of viral reverse transcriptases and cellular DNA polymerases.
• Process Chemistry: Utilized in scale-up and optimization processes for the commercial manufacturing of targeted therapeutic candidates.
• Reference Standard: Provides a high-purity compound for use as an analytical standard in quality control (QC) and regulatory submissions for drug development programs.

Basic Information

Product Name	2',3'-Dideoxy-3'-Fluoro-5-Methylcytidine
CAS No.	115249-95-1
Molecular Formula	C10H14FN3O3
Molecular Weight	243.24 g/mol
Synonyms	3'-Fluoro-2',3'-dideoxy-5-methylcytidine; 5-Methyl-3'-fluoro-2',3'-dideoxycytidine; 3'-F-dd-5-MeC; 2',3'-Dideoxy-3'-fluoro-5-methylcytidine; 3'-Fluoro-dd-5-methylcytidine; 5-Methyldideoxyfluorocytidine; 3'-F-2',3'-dd-5-MeCyd; 115249-95-1
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-3'-Fluoro-5-Methylcytidine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Quality is assured through comprehensive analytical testing including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.