Description

2-Iodo-3'-Deoxyadenosine is a halogenated nucleoside analog of significant interest in pharmaceutical research and development. This modified nucleoside serves as a critical building block and intermediate for the synthesis of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in medicinal chemistry and nucleotide-based drug discovery.

Application

• Medicinal Chemistry Intermediate: A key precursor in the synthesis of nucleoside analog prodrugs targeting viral polymerases.
• Antiviral Research: Used in the development of potential therapeutics for viral infections, including HIV, hepatitis, and herpes viruses.
• Oncology Drug Discovery: Serves as a scaffold for creating compounds that interfere with DNA synthesis in rapidly dividing cancer cells.
• Biochemical Probe Development: Employed in the creation of labeled or modified nucleotides for studying enzyme mechanisms and nucleic acid interactions.
• Academic & Pharmaceutical R&D: A valuable reagent for basic research into nucleotide metabolism and for high-throughput screening libraries.

Basic Information

Product Name	2-Iodo-3'-Deoxyadenosine
CAS No.	115044-77-4
Molecular Formula	C10H11IN5O3
Molecular Weight	376.13 g/mol
Synonyms	2-Iodo-2',3'-dideoxyadenosine; 2-Iodo-ddA; 9-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-2-iodo-9H-purin-6-amine; 2-Iodo-3'-deoxyadenosine; 2-I-3'-dA; 2-IododdA; 2-Iodo-2',3'-dideoxyadenosine (ddA analog)
EINECS	Contact for details

Quality Control

Our 2-Iodo-3'-Deoxyadenosine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade chemicals, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.