Description

2-Bromo-3'-Deoxyadenosine is a modified nucleoside analog of deoxyadenosine, where a bromine atom is substituted at the 2-position of the adenine base. This specific halogenation makes it a valuable synthetic intermediate and research tool in medicinal chemistry and biochemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of antiviral and anticancer agents, as well as for oligonucleotide synthesis and biochemical studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate adenosine deaminase and other nucleoside-metabolizing enzymes.
• Oligonucleotide Synthesis: Serves as a modified monomer for incorporating specific functionalities into DNA/RNA sequences for diagnostic or therapeutic applications.
• Medicinal Chemistry: A crucial precursor for structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic nucleosides.
• Antiviral Agent Development: Explored for its potential activity against DNA viruses due to its ability to be incorporated into viral DNA.
• Labeling and Probes: Can be used to create radiolabeled or fluorescently tagged probes for tracking biological processes.

Basic Information

Product Name	2-Bromo-3'-Deoxyadenosine
CAS No.	115044-76-3
Molecular Formula	C10H12BrN5O3
Molecular Weight	330.14 g/mol
Synonyms	2-Bromo-2'-deoxyadenosine; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-2-bromoadenine; 2-Br-dA; 2-Bromo-9-(2-deoxy-β-D-ribofuranosyl)adenine; Adenosine, 2-bromo-2'-deoxy-; 2-Bromodeoxyadenosine
EINECS	Contact for details

Quality Control

Our 2-Bromo-3'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.