Description

2-Chloro-3'-Deoxyadenosine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in nucleoside chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of nucleoside-based antiviral and anticancer therapeutics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related pathways.
• Antiviral Agent Development: Serves as a core structure for creating analogs targeting viral polymerases, particularly in HIV and hepatitis research.
• Anticancer Drug Discovery: Investigated for its potential to be incorporated into DNA, disrupting replication in rapidly dividing cancer cells.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside drugs.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2-Chloro-3'-Deoxyadenosine
CAS No.	115044-75-2
Molecular Formula	C10H12ClN5O3
Molecular Weight	285.69 g/mol
Synonyms	2-Chloro-2',3'-dideoxyadenosine; 2-Chloro-ddA; 9-(2,3-Dideoxy-β-D-erythro-pentofuranosyl)-2-chloroadenine; 2-Cl-ddA; 2-Chloro-2',3'-dideoxyadenosine; 2-Chloro-3'-deoxyadenosine; 2-Chloro-2',3'-dideoxyadenosine (2-Cl-ddA); Adenosine, 2-chloro-2',3'-dideoxy-
EINECS	Contact for details

Quality Control

Our 2-Chloro-3'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.