Description

2-Fluoro-2',3'-Dideoxyadenosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. Its primary value lies in its role as a precursor for synthesizing modified oligonucleotides and potential antiviral or anticancer prodrugs. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who are developing novel therapeutic agents and molecular probes.

Application

• Antiviral Drug Research: Serves as a critical synthetic intermediate in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Anticancer Agent Development: Used as a building block for creating novel nucleoside analogs that target DNA replication in cancer cells.
• Oligonucleotide Synthesis: A vital monomer for the solid-phase synthesis of fluorinated oligonucleotides, used in antisense therapy, siRNA, and diagnostic applications.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and enzyme mechanisms.
• Prodrug Synthesis: Acts as a core structure for designing prodrugs aimed at improving bioavailability and targeted delivery of active pharmaceutical ingredients.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for pharmaceutical analysis.

Basic Information

Product Name	2-Fluoro-2',3'-Dideoxyadenosine
CAS No.	114849-59-1
Molecular Formula	C10H12FN5O2
Molecular Weight	253.24 g/mol
Synonyms	2'-Fluoro-2',3'-dideoxyadenosine; 2-Fluoro-ddA; 2-F-2',3'-ddA; 9-[(2R,5S)-5-(Fluoromethyl)tetrahydrofuran-2-yl]-9H-purin-6-amine; 2-Fluoro-2',3'-dideoxyadenosine; 2-F-ddA; 2-Fluoro-2',3'-ddAdo
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-2',3'-Dideoxyadenosine is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.