Description

Losartan CAS NO 114798-26-4 is a potent and selective angiotensin II receptor antagonist (ARB) used as an active pharmaceutical ingredient (API). It is a cornerstone medication for managing hypertension and protecting renal function in patients with type 2 diabetes. This high-purity compound is essential for pharmaceutical manufacturers producing finished dosage forms, such as tablets, for the global cardiovascular therapeutics market.

Application

• Primary Pharmaceutical Ingredient: Core API in the manufacture of antihypertensive and cardioprotective medications.
• Hypertension Treatment: Formulated into oral solid dosages (e.g., tablets) for the management of high blood pressure.
• Diabetic Nephropathy: Used in medications to delay the progression of kidney disease in patients with type 2 diabetes and hypertension.
• Heart Failure Management: Incorporated into treatment regimens to reduce the risk of stroke in patients with left ventricular hypertrophy.
• Generic Drug Production: Serves as a critical component for manufacturers of bioequivalent generic versions of branded losartan products.
• Clinical Research: Utilized as a reference standard or raw material in pharmacological studies and new formulation development.
• Combination Therapies: Used in fixed-dose combination drugs, often paired with diuretics like hydrochlorothiazide for enhanced therapeutic effect.

Basic Information

Item	Detail
Product Name	Losartan
CAS No.	114798-26-4
Molecular Formula	C22H23ClN6O
Molecular Weight	422.91 g/mol
Synonyms	Losartan Potassium (salt form); 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol; DuP 753; MK 954; Cozaar (brand name); Losartan Free Base; (2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
EINECS	Contact for details

Quality Control

Our Losartan API is manufactured under strict quality management systems. We provide material that meets or exceeds USP/EP/ICH guidelines for pharmaceutical ingredients. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure regulatory compliance and batch-to-batch consistency for our global clients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	NMT 1.0%
Residue on Ignition	NMT 0.1%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.