Description

5-(Azidomethyl)-2-Chloropyridine is a versatile and high-value heterocyclic building block featuring both an azidomethyl and a chloro substituent on the pyridine ring. This bifunctional structure makes it a critical intermediate for the synthesis of complex molecules, particularly through efficient click chemistry and cross-coupling reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Click Chemistry Substrate: The azide group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition reactions with alkynes to form triazole linkages, a cornerstone of bioconjugation and material science.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the pyridine core's bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Polymer and Material Science: Functional monomer for creating specialty polymers with tailored properties, such as self-healing materials or smart coatings.
• Bioconjugation and Probe Synthesis: Facilitates the labeling of biomolecules (proteins, antibodies, nucleic acids) for diagnostic assays and imaging applications.

Basic Information

Product Name	5-(Azidomethyl)-2-Chloropyridine
CAS No.	114780-17-5
Molecular Formula	C6H5ClN4
Molecular Weight	168.58 g/mol
Synonyms	2-Chloro-5-(azidomethyl)pyridine; 2-Chloro-5-azidomethylpyridine; 5-Azidomethyl-2-chloropyridine; (2-Chloro-5-pyridinyl)methyl azide; 2-Chloropyridine-5-methyl azide; Azidomethyl 2-chloropyridin-5-yl ketone (common misnomer); 114780-17-5 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 5-(Azidomethyl)-2-Chloropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.